TITLE	Antioxidant and antiproliferative activities of sweet potato (Ipomoea batatas [L.] Lam `Tainong 57') constituents
AUTHOR	Dong-Jiann HUANG Institute of Botany, Academia Sinica, Nankang, Taipei 115, Taiwan Chun-Der LIN Institute of Botany, Academia Sinica, Nankang, Taipei 115, Taiwan Hsien-Jung CHEN Department of Horticulture, Chinese Culture University, Taipei 111, Taiwan Yaw-Huei LIN Institute of Botany, Academia Sinica, Nankang, Taipei 115, Taiwan
FULL TEXT	[in HTML format] [in PDF format]
ABSTRACT	The aim of this study is to examine possible antioxidant and antiproliferative activities of the different extracts from sweet potato (Ipomoea batatas [L.] Lam `Tainong 57') organs. DPPH staining, total phenolic compounds and flavonoid content, DPPH radical, reducing power method, FTC method, and cell proliferation were all employed. In the DPPH staining, ethanol extract of vein had the highest radical-scavenging activity when it was diluted to 6.25 mg dry matter/mL. Among all the extracts, the highest amount of total phenolic and flavonoid compounds was found in the ethanol extract of vein. In the DPPH colorimetric method, it was found that ethanol extract of leaf had the highest radical-scavenging activity, followed by water extract of vein. In the reducing power activity assay, it was found that the water extract of leaf had the highest reducing power activity, followed by ethanol extract of vein. Like phenolic compounds, the highest FTC activity was found in the ethanol extract of vein. The antiproliferative activities aof sweet potato were studied in vitro using human lymphoma NB4 cells, and the following results were found: water extract of vein had the highest antiproliferative activity with an EC50 of 449.6 ± 27.73 µg/mL, followed by water extract of storage root, water extract of leaf, ethanol extract of storage root, and ethanol extract of leaf. Although the ethanol extract of vein showed strong antioxidant activity, it had no antiproliferative activity under the experimental conditions tested.
KEYWORD	Antioxidant; Antiproliferative; Free radical; Sweet potato;
ARTICLE INFO	Botanical Bulletin of Academia Sinica, Volume 45 Number 3 July 2004, page 179-186, 8 pages
PUBLISHER	Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan, Republic of China